"A Golden Globe is a mood-altering substance, there's no doubt about that"

This quote by Rachel Griffiths is referring to the distinguished Golden Globe Awards, which are presented each year by the Hollywood Foreign Press Association. Griffiths is recommending that the awards have an effective result on the state of minds of those who receive them. She suggests that the awards can be viewed as a type of "mood-altering substance," as they can bring an excellent sense of joy and achievement to the winners. The quote also indicates that the awards can be viewed as a type of recognition, as they are a recognition of the hard work and commitment of those who have accomplished success in the entertainment industry. Griffiths is recommending that the awards have an effective effect on the emotions of those who get them, and there is no doubt about that.