"Charlie Sheen is who again? Denise is engaged?"

In this quote, Neil Patrick Harris is expressing confusion and surprise at the news that Charlie Sheen is engaged. He appears to have forgotten who Charlie Sheen is, which could be analyzed as a dig at Sheen's fading popularity. Harris likewise seems to be questioning the credibility of the news, as if he can't think that Sheen is actually engaged. This might be due to Sheen's tumultuous individual life and past controversies. In general, Harris's tone suggests a mix of disbelief and indifference towards the news of Sheen's engagement.