"I don't know about Brad Pitt leaving that beautiful woman to go hold orphans for Angelina. I mean how long is that going to last?"

Michael Douglas is expressing his disbelief at Brad Pitt leaving his then-wife Jennifer Aniston to be with Angelina Jolie. He is questioning the durability of the relationship, as he does not comprehend why Pitt would leave a lovely female to go hold orphans for Angelina. He is suggesting that Pitt's choice to leave Aniston was a rash one, which the relationship with Jolie might not last. He is likewise indicating that Pitt's choice to leave Aniston was encouraged by Angelina's charity work, instead of genuine love. Michael Douglas is revealing his apprehension about the relationship, and questioning the durability of it. He is indicating that Pitt's choice to leave Aniston was a mistake, and that the relationship with Jolie might not last.