"The show had run its course on the Fox network"

In this quote, Will Arnett is describing a television program that has concerned an end on the Fox network. The phrase "run its course" recommends that the show has actually reached its natural conclusion and has no more story to inform. This might indicate that the program has been on the air for a very long time and has tired all of its possible storylines, or that it has just lost its appeal and is no longer attracting audiences. In either case, the program has actually reached its end on the Fox network and will no longer be airing.