"There are several such issues where I have departed radically from the Republican orthodoxy"

William Weld's quote recommends that he has taken a position on particular concerns that is not in line with the Republican Party's traditional beliefs. This might indicate that he has actually embraced a more progressive stance on certain issues, or that he has taken a position that is more moderate than the Republican Party's conventional beliefs. This might be viewed as an indication of Weld's willingness to challenge the status quo and to believe beyond package when it concerns certain issues. It might also be viewed as a sign of his self-reliance and his desire to stand up for what he believes in, even if it goes against the Republican Party's traditional beliefs. Eventually, Weld's quote suggests that he is willing to decide on particular concerns, even if it implies going against the Republican Party's standard beliefs.