"There exist thousands of Americans who have AIDS-defining diseases but are HIV negative"

This quote by Serge Lang is referring to the fact that there are many individuals in the United States who have illness that are related to HIV, however who are not in fact contaminated with the virus. This is an essential point to consider, as it highlights the reality that HIV is not the only reason for these diseases. It is possible for people to have AIDS-defining illness without being HIV favorable, and this is something that must be taken into account when discussing HIV and AIDS. It is likewise important to keep in mind that HIV is not the only virus that can cause AIDS-defining diseases, and that other infections can also trigger comparable signs. This quote serves as a pointer that HIV is not the only cause of AIDS-defining illness, which there are many people in the United States who have these diseases but are not infected with HIV.