"Unless you're Jack Lemmon or Cary Grant, there are few guys who can do comedy and drama"

This quote by Steve Guttenberg is referring to the problem of being an effective actor who can do both funny and drama. He is stating that it is an unusual skill to be able to do both genres of acting, and that it is an ability that is just had by a few stars, such as Jack Lemmon and Cary Grant. He is implying that it is a difficult task to be able to change in between the 2 genres and be successful in both. He is also suggesting that it is an ability that is not easily obtained, which it takes a lot of hard work and dedication to be able to do both funny and drama. This quote is a testament to the talent of Jack Lemmon and Cary Grant, and to the difficulty of being a successful actor who can do both genres.