"How is the base sequence, divided into codons? There is nothing in the backbone of the nucleic acid, which is perfectly regular, to show us how to group the bases into codons"

In this quote, Francis Crick is referring to the process of dividing the base sequence of a nucleic acid into codons. He is stressing that there is no fundamental structure in the backbone of the nucleic acid that can be utilized to organize the bases into codons. This suggests that the process of dividing the base series into codons should be done manually, and is not a natural procedure. Crick is recommending that the process of dividing the base sequence into codons is not a simple task, as there is no regular pattern in the foundation of the nucleic acid that can be utilized as a guide. He is stressing that the process of dividing the base series into codons must be done thoroughly and accurately, as it is vital for the appropriate functioning of the nucleic acid.