"IT has been observed by several gentlemen, in vindication of this motion, that if it should be carried, neither my life, liberty, nor estate will be affected"

This quote by Robert Walpole is referring to a movement that is being discussed. He is suggesting that if the motion is passed, it will not have any unfavorable result on his life, liberty, or estate. This suggests that the motion is not something that would be detrimental to him, and he is in assistance of it. Walpole is also mentioning the observations of several gentlemen, implying that they have pertained to the exact same conclusion. This recommends that the motion is most likely helpful to him and the other gentlemen, and that it is something that should be passed. Overall, this quote is an endorsement of the motion being discussed, and Walpole is positive that it will not have any negative effects for him or the other gentlemen.