"Lo, what huge heaps of littleness around!"

This quote by Alexander Pope is a reflection on the insignificance of human life in the grand plan of things. He is mentioning that, in spite of our best shots, our lives are eventually unimportant in the grand scheme of the universe. He is suggesting that, despite our efforts to make our lives significant, our accomplishments are ultimately little and irrelevant. He is also recommending that, regardless of our efforts to make our lives significant, our lives are eventually irrelevant in the grand scheme of the universe. He is emphasizing the significance of humbleness and acknowledging our own limitations. He is also highlighting the importance of recognizing our own mortality and the insignificance of our lives in the grand plan of things. Ultimately, this quote is a pointer to be modest and to acknowledge our own death.