"The trouble with born-again Christians is that they are an even bigger pain the second time around"

This quote by Herb Caen is an amusing jab at born-again Christians. It suggests that those who have actually gone through the procedure of being "born-again" are more difficult to deal with than those who have not. Caen is suggesting that the procedure of being born-again does not always make an individual more pleasant or simpler to agree. Rather, it might make them harder to deal with, as they might be more zealous in their beliefs and more insistent on trying to convert others. Caen's quote is an amusing method of pointing out that the process of being born-again does not necessarily make an individual more pleasant or much easier to get along with.