"We have no firm hold on any knowledge or philosophy that can lift us out of our difficulties"

In this quote, Anne Sullivan is expressing the idea that as people, we do not possess any concrete understanding or belief system that can assist us conquer the challenges and struggles we face in life. She recommends that in spite of our improvements in understanding and approach, we still lack a strong grasp on how to browse through difficult situations. This could be analyzed as a call to continue seeking and finding out, along with a reminder of the limitations of our understanding. It also highlights the universal experience of facing troubles and the need for strength and determination in the face of them.