"A lot of our writers, like Conan O'Brien, moved on to other things"

This quote by Matt Groening is describing the authors of the popular animated tv program, The Simpsons. Groening is acknowledging that a lot of the writers who dealt with the program have actually gone on to pursue other projects. This is likely a reference to Conan O'Brien, who was a writer on The Simpsons from 1991 to 1993 prior to going on to host his own late night talk program. Groening's quote is a testimony to the success of the program's writers, as much of them have actually gone on to have effective professions in the show business. It likewise speaks with the show's long lasting impact, as a lot of the writers have gone on to become family names. Groening's quote is a reminder of the show's influence and the success of its authors.