"Every real thought on every real subject knocks the wind out of somebody or other"

The quote by Oliver Wendell Holmes means that when someone expresses a genuine thought or opinion on a significant topic, it can have an influence on another person, commonly in an unfavorable way. It suggests that every statement or suggestion can have consequences as well as might annoy, challenge or dismayed someone. Thus, expressing one's sights calls for guts, as it can result in argument, dispute, or perhaps hostility. The quote highlights the significance of being thoughtful and mindful in revealing opinions, specifically on sensitive subjects. It also emphasizes the concept that words can be effective as well as have effects, as well as one ought to choose their words thoroughly.