"For there is no one so great or mighty that he can avoid the misery that will rise up against him when he resists and strives against God"

This quote by John Calvin is a pointer that no matter how effective or prominent a person might be, they can not leave the repercussions of going against God. Calvin is emphasizing that nobody is exempt from the suffering that will come when they choose to disobey God's will. He is warning that no matter how excellent a person might be, they will not be able to avoid the anguish that will come when they go against God. This quote works as a reminder that God is all-powerful and that nobody can escape His judgement. It is a reminder that we ought to always strive to do what is right and to follow God's will, as it is the only method to avoid the suffering that comes with disobedience.