"I have yet to write that one song that defines my career"

This quote by Sheryl Crow speaks to the concept that an artist's career is defined by their best work. It suggests that despite her success, Crow has yet to compose the song that will define her career. This could be translated as an obstacle to herself to develop something that will stand the test of time and be kept in mind as her defining work. It might likewise be interpreted as a reflection on the problem of producing something that will be remembered and appreciated for several years to come. It is a pointer that even the most successful musicians have yet to produce something that will specify their profession. Eventually, this quote talks to the concept that producing something genuinely great is a challenging and continuous process.