"It now seems certain that the amino acid sequence of any protein is determined by the sequence of bases in some region of a particular nucleic acid molecule"
About this Quote
The intent is less to dazzle than to lock in a new organizing principle. By linking amino acid sequence to a "region" of nucleic acid, Crick isn’t merely describing a correlation; he’s proposing a pipeline of information. The subtext is a bet on legibility: if the instructions for a protein are in the bases, then heredity is not just transmitted, it’s encoded. That single conceptual move sets the stage for what we now shorthand as the genetic code, and for the broader shift that made modern molecular biology feel inevitable.
Context matters: Crick is writing into a moment when the double helix had made DNA plausible as the genetic material, but the mechanism was still foggy. His careful generality ("some region", "a particular nucleic acid molecule") reflects an open frontier - RNA’s role, regulation, and exceptions weren’t mapped yet. The power of the line is its minimalist audacity: it turns life into an information problem, inviting experiments that can prove, break, or refine the claim.
Quote Details
| Topic | Science |
|---|---|
| Source | Crick, Francis H. C., "On Protein Synthesis", 1958; Symposia of the Society for Experimental Biology, vol. 12, pp. 138-163. (Contains the statement that amino acid sequence of a protein is determined by base sequence in a nucleic acid.) |
| Cite | Cite this Quote |
Citation Formats
APA Style (7th ed.)
Crick, Francis. (n.d.). It now seems certain that the amino acid sequence of any protein is determined by the sequence of bases in some region of a particular nucleic acid molecule. FixQuotes. https://fixquotes.com/quotes/it-now-seems-certain-that-the-amino-acid-sequence-15482/
Chicago Style
Crick, Francis. "It now seems certain that the amino acid sequence of any protein is determined by the sequence of bases in some region of a particular nucleic acid molecule." FixQuotes. Accessed February 1, 2026. https://fixquotes.com/quotes/it-now-seems-certain-that-the-amino-acid-sequence-15482/.
MLA Style (9th ed.)
"It now seems certain that the amino acid sequence of any protein is determined by the sequence of bases in some region of a particular nucleic acid molecule." FixQuotes, https://fixquotes.com/quotes/it-now-seems-certain-that-the-amino-acid-sequence-15482/. Accessed 1 Feb. 2026.

