"It now seems very likely that many of the 64 triplets, possibly most of them, may code one amino acid or another, and that in general several distinct triplets may code one amino acid"
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The "64 triplets" is the tell. With four nucleotide letters and triplets as words, you get 4^3 = 64 possible codons. But there are only 20 standard amino acids. The math forces a cultural reckoning inside science: nature isn’t obligated to be minimalistic. Instead, it’s pragmatic. Several triplets mapping to the same amino acid means the system is error-tolerant; mutations can happen without changing the protein, and translation can be buffered against noise. That’s a design principle hiding in a technical aside.
Crick also signals a shift from speculative theorizing to an emerging consensus. The careful qualifiers aren’t weakness; they’re a scientist publicly negotiating uncertainty while guiding the field toward a unifying framework. The subtext is authority earned through restraint: he’s not selling revelation, he’s staking a claim that will soon look inevitable. In hindsight, it’s the genetic code’s most modern feature - not perfection, but resilience.
Quote Details
| Topic | Science |
|---|---|
| Source | Help us find the source |
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Citation Formats
APA Style (7th ed.)
Crick, Francis. (2026, January 18). It now seems very likely that many of the 64 triplets, possibly most of them, may code one amino acid or another, and that in general several distinct triplets may code one amino acid. FixQuotes. https://fixquotes.com/quotes/it-now-seems-very-likely-that-many-of-the-64-15483/
Chicago Style
Crick, Francis. "It now seems very likely that many of the 64 triplets, possibly most of them, may code one amino acid or another, and that in general several distinct triplets may code one amino acid." FixQuotes. January 18, 2026. https://fixquotes.com/quotes/it-now-seems-very-likely-that-many-of-the-64-15483/.
MLA Style (9th ed.)
"It now seems very likely that many of the 64 triplets, possibly most of them, may code one amino acid or another, and that in general several distinct triplets may code one amino acid." FixQuotes, 18 Jan. 2026, https://fixquotes.com/quotes/it-now-seems-very-likely-that-many-of-the-64-15483/. Accessed 12 Feb. 2026.