"Life is made up of sobs, sniffles, and smiles, with sniffles predominating"

This quote by O. Henry speaks to the suggestion that life is a mix of both excellent and disappointments. The expression "sobs, sniffles, and smiles" is a metaphor for the various emotions we experience throughout life. The phrase "sniffles predominating" suggests that the disappointments in life are much more regular than the great. This quote is a pointer that life is not always easy which we need to approve the negative with the great. It is a reminder to remain resilient and also to maintain striving for the good minutes in life. It is also a reminder to appreciate the great moments when they come, as they are frequently short lived. Life is a trip and it is very important to bear in mind that the negative minutes will certainly pass as well as the good minutes will come.