"Mysteriously and in ways that are totally remote from natural experience, the gray drizzle of horror induced by depression takes on the quality of physical pain"

This quote by William Styron talks to the special and mystical nature of anxiety. It is a sensation that is not quickly understood or discussed, and it is not something that can be experienced through natural methods. Styron is describing the sensation of depression as a "gray drizzle of horror," which has a physical quality to it. He is suggesting that depression can be so frustrating and extreme that it can feel like physical pain. This quote speaks to the power of depression and how it can impact an individual's life in an extensive way. It is a suggestion that depression is a serious condition that ought to not be taken lightly.