"The burden of originality is one that most people don't want to accept. They'd rather sit in front of the TV and let that tell them what they're supposed to like, what they're supposed to buy, and what they're supposed to laugh at"

The quote is suggesting that individuals are typically scared or reluctant to think on their own and be initial in their thoughts and actions. Rather, they prefer to be told what to like, purchase or find funny by the mass media like tv. Marilyn Manson indicates that this unwillingness to be initial is a problem that many individuals carry in their lives.