"At our best, it's a good experience but we do 22 episodes a year, so there are some clunkers"

Vincent D'Onofrio's quote is referring to the experience of dealing with a tv show. He is saying that when the program is at its best, it is a great experience, however since they produce 22 episodes a year, there are some episodes that are not as great as the others. This might be due to a range of aspects, such as a hurried production schedule, an absence of resources, or an absence of imaginative motivation. It is likely that the program's writers and producers are doing their finest to create quality material, however the sheer volume of episodes they are producing can make it difficult to maintain a regularly high level of quality. Despite this, D'Onofrio is still positive about the program, and thinks that when it is at its finest, it is a good experience.