"But I'm aware of the fact that I'm working in a commercial venue where I'm producing something that I wouldn't normally be approaching the way I'm doing it"

In this quote, Bill Sienkiewicz is acknowledging the truth of his work as a business artist. He acknowledges that the nature of his task needs him to approach his jobs in a various method than he would if he were producing art for individual fulfillment. This might mean compromising his creative vision or design in order to attract a broader audience or satisfy the demands of a client. Sienkiewicz knows this compromise and comprehends that it is necessary in order to succeed in the business world. Despite this, he still keeps a level of self-awareness and remains real to his own creative stability.