"How many gangsters you know, from Al Capone up to John Gotti, been gay?"

Method Man is asking a rhetorical concern about the prevalence of homosexuality among gangsters. He is referencing 2 of the most popular gangsters in history, Al Capone and John Gotti, to make a point about the rarity of homosexuality among gangsters. He is suggesting that there are very couple of, if any, gangsters who are freely gay. He is likewise recommending that homosexuality is not accepted in the gangster way of life. The quote is a commentary on the macho, hyper-masculine culture of gangsters and the stigma that is attached to homosexuality in that world. It is a tip that even in the most extreme and violent of way of lives, there is still a lack of acceptance for those who are different.