"I feel upsettingly de-natured. If Penelope Cruz were one of my nurses, I wouldn't even notice"

In this quote, Christopher Hitchens is expressing an extensive sense of disconnection from his typical human experiences and desires. The expression "I feel upsettingly de-natured" recommends that Hitchens is coming to grips with a state of being that feels alien and unnatural to him. This feeling might arise from factors such as health problem, emotional chaos, or a transformative life event-- elements that disrupt his sense of normalcy and self-identity.

Making use of the word "upsettingly" underscores the emotional harshness and pain that accompany this shift in identity. It conveys a deep-seated worry with this brand-new state, recommending that it is not just various, but distressingly so. Hitchens is understood for his wit and sharp observations about life, yet here, he is not able to find comfort in his typical perception of the world.

The subsequent part of the quote, "If Penelope Cruz was among my nurses, I wouldn't even discover," serves to show the level of this de-natured state. Penelope Cruz, a well-known actress renowned for her beauty, represents an archetype of femininity and allure that would ordinarily capture anyone's attention. Hitchens implies that even somebody as dazzling as Cruz would stop working to permeate his awareness in his existing state. This suggests an extensive level of inner fixation or numbness, where external stimuli, no matter how pleasing or luring, go undetected.

The hyperbolic choice of Penelope Cruz raises the declaration to a level of humor, attribute of Hitchens' design, while simultaneously highlighting the depth of his detachment. Ultimately, the quote encapsulates the weight of losing touch with one's own desires and pleasures, painting a picture of a guy challenged with an existential crisis that renders him indifferent to the world's beauty and attraction.