"I... had guys on the set who didn't like me... they weren't interested in the cold character"

Catherine Keener's quote speaks with the difficulty of playing a character that is emotionally remote and unapproachable. It suggests that the people she was dealing with on set were unable to connect with her character, and as a result, did not like her. This could be due to the fact that they discovered her character to be too cold and uninviting, or since they felt that she was not depicting the character in a manner that was believable or relatable. It could likewise be that they merely did not understand the character and were unable to connect with her. Whatever the reason, it is clear that individuals on set were not thinking about the character she was playing, and this might have been a difficult experience for Keener. It is a pointer of the significance of being able to connect with a character in order to depict them efficiently, and of the difficulties that can emerge when a character is not easily relatable.