"I never thought I was doing the same thing as directors like John Carpenter, George Romero, and sometimes even Hitchcock, even though I've been sometimes compared to those other guys. We're after different game"

David Cronenberg is revealing his surprise at being compared to some of the most renowned directors in history. He acknowledges that he is often compared to John Carpenter, George Romero, and even Alfred Hitchcock, but he firmly insists that he is after a various game. He is indicating that his work is special which he is not trying to duplicate the style of these other directors. He is recommending that his work is distinct and that he is not attempting to imitate the work of these other directors. He is stressing that he is a specific artist with his own special vision and style. He takes pride in his work and does not want to be viewed as a copycat of these other directors. He is revealing his gratitude for the acknowledgment he has actually gotten, but he is likewise making it clear that he is his own artist.