"I think people are going to keep asking me about Macaulay. Some things change and some things don't"

Kieran Culkin's quote suggests that although some things in life may change, some things stay the exact same. In this case, he is referring to the fact that individuals will continue to ask him about his sibling, Macaulay Culkin. This could be analyzed as a reminder that although life is constantly changing, some things will constantly remain the exact same. It could also be seen as a tip that family is a vital part of life which it is essential to value the relationships we have actually with our enjoyed ones. Ultimately, Kieran's quote is a suggestion that although life is ever-changing, some things will always remain the very same.