"I wonder what kind of lives they will have built for themselves when they turn 45 and can't really have any connection with people because they are so used to fleeting sexual"

This quote by Randy Harrison talks to the idea of isolation and the effects of a life lived without significant connections. It suggests that when people become familiar with short lived sexual relationships, they may discover themselves not able to form significant connections with others when they reach the age of 45. This could result in a life of loneliness and seclusion, as they are unable to form the kind of relationships that bring delight and fulfillment. The quote suggests that it is necessary to form significant connections with others in order to avoid this kind of isolation in later life. It is a tip to cherish the relationships we have now and to make certain that we are buying meaningful connections with others, instead of depending on short lived sexual relationships.