"I would never think of crying about any loss of an office, because that's always a possibility, and if you're professional, then you deal with it professionally"

The quote suggests that Nancy Pelosi does not get too mentally attached to any political workplace she holds, because she understands that she may lose it at any time. As an expert politician, she understands how to handle disappointments in a composed and dignified way. She values the office for the opportunity it provides to serve the public, not for the status or power.