"I'm seeing and hearing lots of B to B instruments, and everybody isn't, you know, using them... a lot of these guys are trying to do it on conventional guitars, although that has its own sound, and maybe its okay"

John Sebastian is referring to using B to B instruments, which are instruments that are tuned to a B level tuning. He is stating that not everyone is using these tools, and some people are attempting to make use of standard guitars rather. He recognizes that this has its very own audio, and that it might be alright. He is implying that the audio of the B to B tools transcends, but that it is still appropriate to utilize traditional guitars. He is recommending that individuals should experiment with various instruments and tunings to discover the sound that works ideal for them. Eventually, he is encouraging musicians to explore different audios as well as to find the one that functions ideal for them.