"I've been on a lot of shows that nobody cared about"

This quote by James Denton implies that he has had a lot of experience in the entertainment industry, but not all of it has actually been successful. He is most likely referring to tv shows or movies that he has actually belonged of that have actually not been favored by the public. This could be due to a variety of reasons, such as poor writing, lack of promotion, or merely bad timing. It is likely that Denton has actually experienced a great deal of dissatisfaction in his career, however he is still positive and identified to continue pursuing his dreams. He is most likely using this quote to advise himself and others that failure belongs of life which it is essential to keep trying and never give up.