"Thats why my biggest problems were with LL and Run"

In this quote, Kool Moe Dee is reviewing his past and the obstacles he dealt with in his career. He discusses 2 specific individuals, LL and Run, who were likely fellow artists or colleagues in the music industry. By mentioning that his "greatest issues" were with them, it can be inferred that there was some sort of conflict or difference between them. This could have been because of creative differences, competitors, or individual problems. Regardless, it seems that these 2 people played a considerable function in Kool Moe Dee's struggles and challenges. This quote highlights the intricacies and obstacles of the music industry and the relationships within it.