"The first time I kissed Brad my knees went weak - I literally lost my breath!"

In this quote, Jennifer Aniston is explaining a moment where she shared a kiss with somebody called Brad. She describes that the kiss was so effective that it caused her knees to go weak and she even lost her breath. This suggests that the kiss was filled with extreme emotions and physical feelings. Aniston's usage of the word "literally" highlights the strength of her response, indicating that it was not simply a figure of speech. This quote communicates the idea that the kiss was a considerable and memorable moment for Aniston, possibly marking the beginning of a romantic relationship with Brad.