"The tragedy of life and of the world is not that men do not know God; the tragedy is that, knowing Him, they still insist on going their own way"

William Barclay's quote touches upon a profound aspect of human nature and spirituality. At the heart of his message lies a consideration of the human condition and its relationship with the divine. Barclay recommends that the real grief or catastrophe in life is not substantiated of lack of knowledge of God, however rather from the mindful decision to diverge from a divine course in spite of being aware of it.

The statement implies that people often have a fundamental understanding or awareness of a greater power or ethical compass, which is represented by 'knowing God'. This knowledge recommends a knowledge or an understanding of what might be considered the 'right' or 'moral' method to live one's life. However, Barclay highlights a paradox: in spite of having this awareness, individuals regularly pick to ignore it, choosing instead to follow their own desires or paths that may not line up with their understanding of divine will or moral righteousness.

This habits could be credited to various aspects of human nature, including pride, free choice, and the lure of immediate satisfaction. The persistence on 'going their own way' highlights a style of rebellion or defiance, resonating with the Biblical narrative of initial sin, where Adam and Eve picked their own desires over obedience to God. Barclay's quote may be viewed as a reflection on this olden battle between divine assistance and human autonomy.

Additionally, this declaration can be analyzed as a call to introspection. It advises individuals to consider why, despite comprehending what is ideal or divine, they may pick otherwise. It challenges individuals to acknowledge their struggles with internal disputes, such as withstanding ego, selfishness, or societal pressures that lead them away from a path of wisdom and spiritual fulfillment.

Eventually, Barclay is highlighting the tragedy not simply in the act of picking one's own course, but in the mindful choice to step far from a greater fact. His words function as a tip of the capacity for self-betterment through lining up actions with much deeper, spiritual awareness.