"There are two dilemmas that rattle the human skull: How do you hang on to someone who won't stay? And how do you get rid of someone who won't go?"

In this quote, Danny DeVito highlights two typical predicaments that many people face in relationships. The first problem is how to hold on to somebody who doesn't want to remain. This might describe a romantic partner who is no longer thinking about the relationship or a pal who is drifting away. It can be a painful and aggravating experience to try to keep somebody in your life who doesn't want to be there.

The 2nd dilemma is how to get rid of somebody who refuses to leave. This could describe a poisonous or unwanted individual in your life who is triggering harm or discomfort. It can be challenging to cut ties with someone, especially if they are relentless or have a strong hold on you.

In general, this quote highlights the complexities and difficulties of human relationships and the hard decisions we typically need to make in order to maintain our own well-being.