"Unless there is meaningful change in Syria and an end to the crackdown, President Assad and those around him will find themselves isolated internationally and discredited within Syria"

In this quote by William Hague, the former UK Foreign Secretary, he stresses the urgent requirement for political and social reform in Syria, specifically calling for an end to the overbearing actions by the federal government versus its own people. Hague recommends that without considerable and substantive modifications, the regime led by President Assad deals with severe effects both domestically and worldwide.

The phrase "significant change" indicates that any reforms need to be real and thorough, instead of shallow procedures aimed merely at placating worldwide observers. Hague worries that modification must deal with the source of the dispute and meet the aspirations and rights of the Syrian individuals. The term "end to the crackdown" refers to the cessation of violent and repressive techniques employed by the Assad regime against dissenters, which have actually included arrest, abuse, and killing of protesters and opposition figures.

Hague alerts that failing to achieve these changes will result in Assad and his close circle ending up being "separated internationally". This suggests that the regime would deal with diplomatic and potentially economic sanctions, losing assistance and legitimacy on the worldwide phase. The global community, particularly Western countries and possibly multilateral companies like the United Nations, may withdraw their acknowledgment and enforce sanctions or other procedures to pressure the regime. This seclusion might restrict the program's capability to participate in trade, get international aid, or maintain political alliances.

Locally, Hague predicts President Assad becoming "challenged within Syria". This suggests that without reforms, the Syrian individuals may lose all confidence and trust in Assad's leadership. The government's inability to adjust or resolve the people's demands could lead to increased internal opposition, potentially destabilizing Assad's hold on power and increasing civil discontent.

Overall, Hague's declaration highlights the turning point for Syria at the time, highlighting the pressing need for improvement. It works as both a warning and a call to action, prompting the Syrian government to reform to avoid dire effects.