"You hear about how many fourth quarter comebacks that a guy has and I think it means a guy screwed up in the first three quarters"

This quote by Peyton Manning is referring to the importance of playing well throughout the whole video game, as opposed to just in the fourth quarter. He is suggesting that if a player is relying upon 4th quarter returns to win video games, it implies that they have actually not been playing well in the initial 3 quarters. This is since if they had been playing well, they would not need to rely on a fourth quarter resurgence to win the video game. Manning is emphasizing the importance of playing well throughout the entire video game, instead of just in the fourth quarter. He is recommending that if a player is constantly relying on fourth quarter comebacks to win games, it is a sign that they are not playing well in the very first three quarters. This is since if they had been playing well, they would certainly not need to rely upon a fourth quarter resurgence to win the video game. Manning's quote is a reminder that playing well throughout the whole video game is essential for success, which relying upon 4th quarter resurgences is not a lasting strategy.