Charles Jules Henry Nicolle (birthed in Rouen, France, died in Tunis, Tunisia) was a French physician and also Nobel Reward winner. He was granted the Nobel Prize in Physiology or Medication in 1928 for his initiatives to find a remedy for measles.
Nicolle discovered early in biology from his papa, Eugène Nicolle, who was a medical professional at the healthcare facility in Rouen. He obtained a master's level in 1893 from the Pasteur Institute. Right now, he went back to Rouen as a participant of the medical faculty up until 1896 and afterwards as director of bakteriologlaboratoriet.
In 1903, Nicolle director of the Pasteur Institute in Tunis, where he performed the job of typhoid which later would certainly provide him a Nobel Prize. He was still supervisor of the institute when he passed away in 1936. In 1972 he was elected as a rep of the Royal Vetenskapsakademien.
Nicolle additionally created fiction and approach throughout his life, consisting of publications Le Patissier de Bellone, Les deux Larrons, and also Les Contes de Marmouse.
He married Alice Avic in 1895 and also had 2 children, Marcelle (b. 1896) and Pierre (birthed 1898).
Our collection contains 13 quotes who is written / told by Charles.
"The fact that I was fortunate enough to escape contagion, in spite of frequent, sometimes daily contacts with the disease, was because I soon guessed how it spread"
"Just as the only reservoir for the typhus virus in nature is provided by man, so the only vector of infection is the louse. The bite of the louse is not virulent immediately after the infecting meal. It becomes so only towards the 7th day following infection"
"It did not seem likely that I was destined to undertake research on typhus"
"Most of the doctors in the Tunisian administration, especially those in country districts, contracted typhus and approximately one third of them died of it"
"From the practical point of view, the susceptibility to infection of the guinea pig proved to be the most useful step forward. Today, all laboratories use this animal for preserving the virus"
"Even if it had not been possible to reproduce the disease in animals and consequently to verify the hypothesis, this simple observation would have been sufficient to demonstrate the way in which the disease was propagated"
"Of all the problems which were open to me for study, typhus was the most urgent and the most unexplored. We knew nothing of the way in which contagion spread"
"My first attempts to transmit typhus to laboratory animals, including the smaller species of monkeys, had failed, as had those of my predecessors, for reasons which I can easily supply today"
"I demonstrated the characteristics of experimental fever. It appears after an incubation period which is never less than five days. It follows the same pattern as natural fever in man, but is of shorter duration and less pronounced"
"I was less successful in my attempts to effect preventive vaccination against typhus by using the virus and in trying to produce large quantities of serum using large animals"
"The discovery that I soon made that the guinea pig was also susceptible to infection made it possible for me, from the third year on, to preserve the virus on this animal"
"I finally demonstrated that typhus infection is not hereditary in the louse"
"At the time when I was conducting my research there was no known method for taking the guinea pig's temperature. I demonstrated a technique which is now widely used"
