"And as the circumcised in the flesh, and not in the heart, have no part in God's good promises; even so they that be baptized in the flesh, and not in heart, have no part in Christ's blood"

William Tyndale's quote draws a parallel between two substantial religious rites: circumcision and baptism. Both are tangible, outside expressions of faith with deep spiritual underpinnings. Tyndale utilizes these practices to communicate a wider doctrinal point about the nature of true faith and commitment to God.

The expression "circumcised in the flesh, and not in the heart" recommendations the Jewish tradition of circumcision, which was established as a physical covenant in between God and Abraham's descendants. Tyndale argues that this outward ritual, if not accompanied by inner spiritual conviction or a "circumcised heart", is insufficient for one to take part in "God's good pledges". This implies that simply following spiritual customizeds without a real spiritual improvement is insufficient in the eyes of God.

Likewise, Tyndale draws a connection to the Christian sacrament of baptism, "baptized in the flesh, and not in heart", mentioning that being physically baptized without a genuine acceptance and transformation through Christ does not give one access to the benefits of "Christ's blood". His reference to "Christ's blood" talks to the Christian belief in the sacrifice of Jesus for humankind's salvation. Tyndale underscores that the effectiveness of baptism lies not in the physical act itself however in the genuine faith and internal conversion to which it is expected to affirm.

Hence, Tyndale highlights the significance of inner genuineness over external routines. The real essence of both Jewish and Christian faiths, as he articulates, depends on the inward dedication to God rather than mere adherence to physical ordinances. This point of view aligns with a wider Protestant Reformation view, where the emphasis is put on personal faith and a direct relationship with God instead of mere compliance with ecclesiastical practices. Tyndale's message is a call to genuineness, advising followers to look for authentic spiritual improvement over simple ritual observance.