"As far as big egos, there are definitely guys out there that just think God only knows what about themselves"

In this quote, actor Ethan Suplee is discussing the principle of huge egos and how some individuals have an inflated sense of self-importance. He suggests that there are individuals who have such a high viewpoint of themselves that they believe they are above everybody else, and even God. These individuals may have an exaggerated sense of their own capabilities, achievements, or importance, and may think that they are untouchable or foolproof. Suplee's use of the expression "God just knows what" indicates that these people may have delusions of grandeur or unrealistic beliefs about themselves. In general, the quote highlights the negative effect of having a huge ego and the risk of thinking too extremely of oneself.