"First and foremost, you have to make the movie for yourself. And that's not to say, to hell with everyone else, but what else have you got to go on but your own taste and judgment?"

This quote by Harold Ramis is stressing the importance of trusting your own judgment and taste when making a motion picture. He is saying that you need to make the motion picture on your own most importantly, not to ignore everybody else's opinion, however to use your own taste and judgment as a guide. He is suggesting that you should not be swayed by the opinions of others, however rather trust your own instincts and make the movie that you want to make. This is very important due to the fact that it enables you to develop something that is true to your vision and that you can be pleased with. Eventually, it is essential to keep in mind that you are the one making the film which you must trust your own judgment.