"He is very dry but also very funny... I think people tend to feel odd when I do my act. Unless you are an ironic person, it's not a good place for you to be"

Colin Quinn is suggesting that his funny act is not for every person. He understands that his style of funny is completely dry and ironic, and that not every person will value it. He is suggesting that if you are not an ironic person, then his act may make you really feel uncomfortable. He is additionally recommending that his act is amusing, however it is not the sort of humour that everybody will appreciate. He is implying that his act is best matched for those who appreciate irony and completely dry humour. He is also recommending that if you are not an ironic person, after that it is best to prevent his act.