"I was married to Margaret Joan Howe in 1940. Although not a scientist herself she has contributed more to my work than anyone else by providing a peaceful and happy home"

The quote implies that although Margaret Joan Howe was not a researcher, she played a considerable role in supporting Frederick Sanger's job by developing a helpful and pleasurable atmosphere for him to work in. The tranquil and delighted home that she supplied allowed him to concentrate on his scientific research study and accomplish success in his career.