"In rare instances you have to give up what you thought was a great scene"

Keenen Ivory Wayans is suggesting that sometimes, even when you think you have produced a terrific scene, you might have to let it go. This could be due to a range of factors, such as the scene not fitting into the total story of the project, or it not being as reliable as originally thought. He is recommending that this is a rare incident, however it is something that can occur. This quote is a suggestion to be available to change and to be ready to let go of something that you may have put a great deal of effort into, if it is not the best choice for the project. It is necessary to be able to acknowledge when something is not working and to be going to make changes.