"The only way I would go back to hosting would be if it were something entirely new. It would prevent me from wanting to host a standard-fare kind of talk show"

Garry Shandling's quote suggests that he is not thinking about hosting a standard talk show. He implies that he would only think about hosting a show if it was something completely brand-new and different. This could indicate that he is searching for something more imaginative and ingenious than the standard talk program format. He might be looking for something that would challenge him and keep him engaged. It could also be that he is trying to find something that would be more meaningful and impactful than a typical talk program. Whatever the case, it is clear that Garry Shandling is not interested in hosting a standard-fare talk program and is looking for something more distinct and exciting.