"We all approached doing a sequel with great trepidation and skepticism"

In this quote, Jason Biggs is expressing his sensations about dealing with a sequel. He says that he and his coworkers all felt a sense of worry and unpredictability about handling this task. The word "trepidation" suggests a feeling of stress and anxiety or anxiousness, while "hesitation" suggests doubt or doubt. This could be since follows up are typically compared to the original and can be hard to measure up to. It might likewise be since the actors and team may have been uncertain if they could recreate the success of the first movie. In general, Biggs is acknowledging the obstacles and pressure that include making a follow up.