"Nope, no sex scandals yet. But I am open to offers!"

John Cusack is making a joke about the occurrence of sex scandals in the media. He is indicating that he has not been involved in any sex scandals yet, but he is open to the possibility. This could be translated as a tongue-in-cheek remark about the existing state of affairs in the media, where sex scandals seem to be a regular event. It might also be viewed as an amusing way of stating that he is not interested in engaging in any improper habits. Either way, it is clear that John Cusack is minimizing the circumstance and poking fun at the occurrence of sex scandals in the media.