"Obviously I've spent most of my working life with men and they have this way of operating which seems a bit alien to me"

Janet Street-Porter's quote recommends that she has had a lot of experience dealing with guys, but that their means of operating is unfamiliar to her. This could be interpreted as her sensation that males have a different technique to work than she does, or that they have various assumptions of her. It can also be interpreted as her sensation that males have a various method of communicating and connecting with each other, which she discovers odd. It might additionally be interpreted as her feeling that males have a different way of leading and also handling, which she locates tough to comprehend. Inevitably, the quote suggests that Janet Street-Porter has had a lot of experience dealing with males, but that their way of operating is unknown to her.